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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK12
All Species:
10.3
Human Site:
T1065
Identified Species:
25.19
UniProt:
Q9NYV4
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYV4
NP_055898.1
1490
164155
T1065
E
E
P
P
P
S
K
T
S
R
K
E
T
T
S
Chimpanzee
Pan troglodytes
XP_001139939
1512
164915
K1041
T
D
D
V
S
T
I
K
A
P
R
K
D
L
S
Rhesus Macaque
Macaca mulatta
XP_001088594
1490
164086
T1065
E
E
P
P
P
S
K
T
S
R
K
E
T
T
S
Dog
Lupus familis
XP_548147
1490
164467
S1065
E
E
P
P
P
S
K
S
S
R
K
E
T
T
S
Cat
Felis silvestris
Mouse
Mus musculus
Q14AX6
1484
163663
A1061
E
D
P
P
P
S
K
A
S
R
K
E
T
T
S
Rat
Rattus norvegicus
Q3MJK5
1484
163772
A1061
E
E
Q
P
P
S
K
A
S
R
K
E
T
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687417
1286
141523
K912
D
C
H
E
L
W
S
K
K
R
R
R
Q
K
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397595
1492
167042
I1102
E
M
M
Q
L
E
M
I
S
R
V
C
G
T
P
Nematode Worm
Caenorhab. elegans
P46551
730
82410
I356
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Sea Urchin
Strong. purpuratus
XP_789337
1264
139419
T890
K
A
A
S
R
S
N
T
P
Q
A
P
R
E
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
42.3
98.4
95.1
N.A.
91.1
91.7
N.A.
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
36
27.6
35.7
Protein Similarity:
100
54.2
99.1
96.9
N.A.
94.7
95
N.A.
N.A.
N.A.
N.A.
50.4
N.A.
N.A.
51.7
36
49.5
P-Site Identity:
100
6.6
100
93.3
N.A.
86.6
86.6
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
26.6
13.3
13.3
P-Site Similarity:
100
40
100
100
N.A.
93.3
86.6
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
26.6
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
0
0
10
20
10
0
10
0
0
0
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% C
% Asp:
10
20
10
0
0
0
0
0
0
0
0
0
10
0
0
% D
% Glu:
70
40
0
10
0
10
0
0
0
10
0
50
0
10
0
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
10
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
10
20
0
0
10
0
10
0
0
% I
% Lys:
10
0
0
0
0
0
50
20
10
0
50
20
0
10
0
% K
% Leu:
0
0
0
0
20
0
0
0
0
0
0
0
0
20
0
% L
% Met:
0
10
10
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
40
60
50
0
0
0
10
10
0
10
0
0
10
% P
% Gln:
0
0
10
10
0
0
0
0
0
10
0
0
10
0
10
% Q
% Arg:
0
0
0
0
10
0
0
0
10
70
20
10
10
0
10
% R
% Ser:
0
0
0
10
10
60
10
10
60
0
0
0
0
0
60
% S
% Thr:
10
0
0
0
0
20
0
30
0
0
0
0
50
60
0
% T
% Val:
0
0
0
10
0
0
0
0
0
0
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _